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Clinical Studies

Trial 1

Patients: 150 obese patients.
Testing Period: 4 weeks
Trial type: Randomized with placebo
Dosage: Dietary supplement Garcinia cambogia extract 55 mg, chitosan 240 mg, and chrome 19 mg with a weight reduction regimen.
Outcome: Treatment groups who were given the supplement showed statistically significant dose-related reductions in weight, LDL cholesterol, and triglycerides, and improvement in high density lipoprotein cholesterol.
See Reference #1 below

 

Trial 2

Patients: 40
Testing Period: 8 weeks
Trial type: Randomized with placebo
Dosage: 500mg capsule by mouth before each meal
Outcome: Patients who were given the extract exhibited statistically significant loss in weight and improvement in cholesterol and triglycerides in comparison to the placebo group.
See Reference #2 below

 

Trial 3

Patients: 40 obese patients
Testing Period: 12 weeks
Trial type: Randomized with placebo
Dosage: 50 mg taken by mouth 3 times a day after meals with 1,200 calorie/day diet.
Outcome: The treatment group attained a 3.5 kg weight loss versus the 1.2 kg with the placebo group. Treatment group achieved more than 85% reduction in fat loss in body composition measurements.

Note: The majority of the active group participants did NOT follow the diet regimen.

See Reference #3 below

 

Trial 4

Patients: 89 mildly overweight women
Testing Period: 12 weeks
Trial type: Randomized with placebo
Dosage: 400 mg taken by mouth 3 times a day before each meal with 1,200 calorie/day diet.
Outcome: At the end of the trial, both groups lost weight, but the treatment group achieved greater reduction in body weight. G. cambogia had no effect on appetitive variables.
See Reference #4 below

 

Trial 5

Patients: 54 overweight patients.
Testing Period: 8 weeks
Trial type: Randomized with placebo
Dosage: Combination supplement containing 500 mg Garcinia cambogia 3 times a day. All patients were asked to maintain a low-fat diet and drink 64oz of water each day.
Outcome: The treatment group lost an average weight of 11.14 lb/person as compared with the control group, which lost an average of 4.2 lb/person.

See Reference #5 below

 

Trial 6

Patients: 60 obese patients.
Testing Period: 8 weeks
Trial type: Randomized with placebo
Dosage: 400 mg HCA, 3 times a day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week.
Outcome: Results indicated weight loss for the experimental group compared with the placebo group and that 87% of the weight loss in the HCA group was because of fat loss. Appetite scores were also reduced in the HCA-treated group.
See Reference #6 below

 

Trial 7

Patients: 39 patients.
Testing Period: 16 weeks
Trial type: Randomized with placebo
Dosage: HCA 1,000 mg day before each meal. All patients were on a low-fat diet and also instructed to exercise 3 times a week.
Outcome: Visceral, subcutaneous, and total fat accumulation were reduced in all patients. At the end of the treatment, both groups were administered placebo for 4 weeks and no rebound effect was documented.

See Reference #7 below

 

Studies found that supplementation with G. cambogia can reduce oxidative damage.

See Reference #8 below

 

Trials on the safety profile & weight loss ability of the calcium-potassium double salt of 60% HCA preparation (HCA-SX)

Reference links: See Reference #9,10,11,12,13,14 below

 

References:

1. Girola M, De Bernardi M, Contos S, et al. Dose effect in lipid-lowering activity of a new dietary integrator (chitosan), Garcinia combogia extract and chrome. Acta Toxicol Ther . 1996;17(1):25-40.

2. Soni MG, Burdock GA, Preuss HG, Stohs SJ, Ohia SE, Bagchi D. Safety assessment of (-)-hydroxycitric acid and Super CitriMax, a novel calcium/potassium salt. Food Chem Toxicol . 2004;42(9):1513-1529.

3. Thom E. A randomized, double-blind, placebo-controlled trial of a new weight-reducing agent of natural origin. J Int Med Res . 2000;28(5):229-233.

4. Mattes RD, Bormann L. Effects of (-)-hydroxycitric acid on appetitive variables. Physiol Behav . 2000;71(1-2):87-94.

5-6. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.

7. Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: A double-blind, randomized, placebo-controlled trial. CurrTher Res Clin Exp . 2003;64(8):551-567.

8. Yonei Y, Takahashi Y, Hibino S, Watanabe M, Yoshioka T. Effects on the human body of a dietary supplement containing L-carnitine and Garcinia cambogia extract: a study using double-blind tests. J Clin Biochem Nutr . 2008;42(2):89-103.

9. Ohia SE, Opere CA, LeDay AM, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanism of appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Mol Cell Biochem . 2002;238(1-2):89-103.

10. Lau FC, Bagchi M, Sen C, Roy S, Bagchi D. Nutrigenomic analysis of diet-gene interactions on functional supplements for weight management. Curr Genomics . 2008;9(4):239-251.

11. Talpur N, Echard BW, Yasmin T, Bagchi D, Preuss HG. Effects of niacin-bound chromium, Maitake mushroom fraction SX and (-)-hydroxycitric acid on the metabolic syndrome in aged diabetic Zucker fatty rats. Mol Cell Biochem . 2003;252(1-2):369-377.

12. Bagchi D, Deshmukh NS, Soni MG, Bagchi M. Safety of a novel calcium/potassium salt of (-)-hydroxycitric acid: I. Two generation reproduction toxicity study. Toxicol Lett . 2007;172(suppl 1):S190.

13. Asghar M, Monjok E, Kouamou G, Ohia SE, Bagchi D, Lokhandwala MF. Super CitriMax (HCA-SX) attenuates increases in oxidative stress, inflammation, insulin resistance, and body weight in developing obese Zucker rats. Mol Cell Biochem . 2007;304(1-2):93-99.

14. Preuss HG, Rao CV, Garis R, et al. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med . 2004;35(1-6):33-48.